1qhv: Difference between revisions

Revision as of 09:21, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1qhv.png

Template:STRUCTURE 1qhv

HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEADHUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD

Template:ABSTRACT PUBMED 10502512

About this StructureAbout this Structure

1QHV is a Single protein structure of sequence from Human adenovirus 2. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution., van Raaij MJ, Louis N, Chroboczek J, Cusack S, Virology. 1999 Sep 30;262(2):333-43. PMID:10502512

Page seeded by OCA on Tue Jul 29 09:21:28 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD'''
+===HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD===
-==Overview==
+<!--
-Adenovirus binds to its receptor via the head domain of its fiber protein. We have crystallized the adenovirus serotype 2 (subgroup C) receptor binding domain and solved the structure at 1.5 A resolution by the molecular replacement technique using the known adenovirus type 5 head structure. Included in the high-resolution model are 306 water molecules, five alternative side chain conformations, and individual anisotropic temperature factors for each atom. The overall structure of the serotype 2 head is very similar to its serotype 5 homologue, apart from differences in some of the flexible loops. All but subgroup B adenoviruses are believed to use the recently identified protein CAR (Coxsackievirus and adenovirus receptor) as receptor. By comparison of the two structures and sequence alignment of CAR binding and non-CAR binding serotype fiber heads, we discuss possible receptor binding sites and propose a receptor binding site in a crevice between two monomers on the side of the trimer. The structural basis of the extraordinary stability of the fiber head trimer is also discussed.
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 [[Category: Extra-ordinary stability]]
 [[Category: Receptor binding]]
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