1zy3: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1zy3.gif|left|200px]]
+{{Seed}}
+[[Image:1zy3.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1zy3|  PDB=1zy3  |  SCENE=  }}
-'''Structural model of complex of Bcl-w protein with Bid BH3-peptide'''
+===Structural model of complex of Bcl-w protein with Bid BH3-peptide===
-==Overview==
+<!--
-A peptide corresponding to the BH3 region of the proapoptotic protein, BID, could be bound in the cleft of the antiapoptotic protein, BCL-w. This binding induced major conformational rearrangements in both the peptide and protein components of the complex and led to the displacement and unfolding of the BCL-w C-terminal alpha-helix. The structure of BCL-w with a bound BID-BH3 peptide was determined using NMR spectroscopy and molecular docking. These studies confirmed that a region of 16 residues of the BID-BH3 peptide is responsible for its strong binding to BCL-w and BCL-x(L). The interactions of BCL-w and the BID-BH3 peptide complex with dodecylphosphocholine micelles were characterized and showed that the conformational change of BCL-w upon lipid binding occurred at the same time as the release and unfolding of the BH3 peptide.
+The line below this paragraph, {{ABSTRACT_PUBMED_16475813}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16475813 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16475813}}
 ==About this Structure==
-ZY3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZY3 OCA].
+ZY3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZY3 OCA].
 ==Reference==
@@ Line 27: / Line 31: @@
 [[Category: Bcl-w]]
 [[Category: Bh3-peptide]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:13:26 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:37:32 2008''