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| {{STRUCTURE_2if7| PDB=2if7 | SCENE= }} | | {{STRUCTURE_2if7| PDB=2if7 | SCENE= }} |
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| '''Crystal Structure of NTB-A'''
| | ===Crystal Structure of NTB-A=== |
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| ==Overview==
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| The signaling lymphocytic activation molecule (SLAM) family includes homophilic and heterophilic receptors that regulate both innate and adaptive immunity. The ectodomains of most SLAM family members are composed of an N-terminal IgV domain and a C-terminal IgC2 domain. NK-T-B-antigen (NTB-A) is a homophilic receptor that stimulates cytotoxicity in natural killer (NK) cells, regulates bactericidal activities in neutrophils, and potentiates T helper 2 (Th2) responses. The 3.0 A crystal structure of the complete NTB-A ectodomain revealed a rod-like monomer that self-associates to form a highly kinked dimer spanning an end-to-end distance of approximately 100 A. The NTB-A homophilic and CD2-CD58 heterophilic dimers show overall structural similarities but differ in detailed organization and physicochemical properties of their respective interfaces. The NTB-A structure suggests a mechanism responsible for binding specificity within the SLAM family and imposes physical constraints relevant to the colocalization of SLAM-family proteins with other signaling molecules in the immunological synapse. | | The line below this paragraph, {{ABSTRACT_PUBMED_17045824}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17045824 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17045824}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Ntb-a]] | | [[Category: Ntb-a]] |
| [[Category: Slam6]] | | [[Category: Slam6]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:26:11 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:57:36 2008'' |