2num: Difference between revisions

Revision as of 07:34, 29 July 2008

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File:2num.png

Template:STRUCTURE 2num

Soluble domain of Rieske Iron-Sulfur ProteinSoluble domain of Rieske Iron-Sulfur Protein

Template:ABSTRACT PUBMED 17223530

About this StructureAbout this Structure

2NUM is a Single protein structure of sequence from Rhodobacter sphaeroides. Full crystallographic information is available from OCA.

ReferenceReference

Atomic resolution structures of rieske iron-sulfur protein: role of hydrogen bonds in tuning the redox potential of iron-sulfur clusters., Kolling DJ, Brunzelle JS, Lhee S, Crofts AR, Nair SK, Structure. 2007 Jan;15(1):29-38. PMID:17223530

Page seeded by OCA on Tue Jul 29 07:34:05 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Soluble domain of Rieske Iron-Sulfur Protein'''
+===Soluble domain of Rieske Iron-Sulfur Protein===
-==Overview==
+<!--
-The Rieske [2Fe-2S] iron-sulfur protein of cytochrome bc(1) functions as the initial electron acceptor in the rate-limiting step of the catalytic reaction. Prior studies have established roles for a number of conserved residues that hydrogen bond to ligands of the [2Fe-2S] cluster. We have constructed site-specific variants at two of these residues, measured their thermodynamic and functional properties, and determined atomic resolution X-ray crystal structures for the native protein at 1.2 A resolution and for five variants (Ser-154--&gt;Ala, Ser-154--&gt;Thr, Ser-154--&gt;Cys, Tyr-156--&gt;Phe, and Tyr-156--&gt;Trp) to resolutions between 1.5 A and 1.1 A. These structures and complementary biophysical data provide a molecular framework for understanding the role hydrogen bonds to the cluster play in tuning thermodynamic properties, and hence the rate of this bioenergetic reaction. These studies provide a detailed structure-function dissection of the role of hydrogen bonds in tuning the redox potentials of [2Fe-2S] clusters.
+The line below this paragraph, {{ABSTRACT_PUBMED_17223530}}, adds the Publication Abstract to the page
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 ==About this Structure==
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 [[Category: Nair, S K.]]
 [[Category: Iron sulfur cluster]]
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