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| [[Image:1tw7.gif|left|200px]] | | {{Seed}} |
| | [[Image:1tw7.png|left|200px]] |
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| {{STRUCTURE_1tw7| PDB=1tw7 | SCENE= }} | | {{STRUCTURE_1tw7| PDB=1tw7 | SCENE= }} |
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| '''Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target'''
| | ===Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target=== |
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| ==Overview==
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| This report examines structural changes in a highly mutated, clinical multidrug-resistant HIV-1 protease, and the crystal structure has been solved to 1.3 A resolution in the absence of any inhibitor. This protease variant contains codon mutations at positions 10, 36, 46, 54, 62, 63, 71, 82, 84, and 90 that confer resistance to protease inhibitors. Major differences between the wild-type and the variant include a structural change initiated by the M36V mutation and amplified by additional mutations in the flaps of the protease, resulting in a "wide-open" structure that represents an opening that is 8 A wider than the "open" structure of the wild-type protease. A second structural change is triggered by the L90M mutation that results in reshaping the 23-32 segment. A third key structural change of the protease is due to the mutations from longer to shorter amino acid side chains at positions 82 and 84.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16338417}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16338417 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16338417}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Multi-drug resistance]] | | [[Category: Multi-drug resistance]] |
| [[Category: Polyprotein]] | | [[Category: Polyprotein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:26:45 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:39:57 2008'' |