1w2k: Difference between revisions

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{{Seed}}
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{{STRUCTURE_1w2k|  PDB=1w2k  |  SCENE=  }}  
{{STRUCTURE_1w2k|  PDB=1w2k  |  SCENE=  }}  


'''TF7A_4380 COMPLEX'''
===TF7A_4380 COMPLEX===




==Overview==
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Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling.
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{{ABSTRACT_PUBMED_15664864}}


==About this Structure==
==About this Structure==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Vitamin k]]
[[Category: Vitamin k]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:03:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:38:44 2008''

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