2fcp: Difference between revisions

Revision as of 06:26, 29 July 2008

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File:2fcp.png

Template:STRUCTURE 2fcp

FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) FROM E.COLIFERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) FROM E.COLI

Template:ABSTRACT PUBMED 9856937

About this StructureAbout this Structure

2FCP is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Siderophore-mediated iron transport: crystal structure of FhuA with bound lipopolysaccharide., Ferguson AD, Hofmann E, Coulton JW, Diederichs K, Welte W, Science. 1998 Dec 18;282(5397):2215-20. PMID:9856937

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-'''FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) FROM E.COLI'''
+===FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) FROM E.COLI===
-==Overview==
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-FhuA, the receptor for ferrichrome-iron in Escherichia coli, is a member of a family of integral outer membrane proteins, which, together with the energy-transducing protein TonB, mediate the active transport of ferric siderophores across the outer membrane of Gram-negative bacteria. The three-dimensional structure of FhuA is presented here in two conformations: with and without ferrichrome-iron at resolutions of 2.7 and 2.5 angstroms, respectively. FhuA is a beta barrel composed of 22 antiparallel beta strands. In contrast to the typical trimeric arrangement found in porins, FhuA is monomeric. Located within the beta barrel is a structurally distinct domain, the "cork," which mainly consists of a four-stranded beta sheet and four short alpha helices. A single lipopolysaccharide molecule is noncovalently associated with the membrane-embedded region of the protein. Upon binding of ferrichrome-iron, conformational changes are transduced to the periplasmic pocket of FhuA, signaling the ligand-loaded status of the receptor. Sequence homologies and mutagenesis data are used to propose a structural mechanism for TonB-dependent siderophore-mediated transport across the outer membrane.
+The line below this paragraph, {{ABSTRACT_PUBMED_9856937}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_9856937}}
 ==About this Structure==
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 [[Category: Iron transport protein]]
 [[Category: Tonb-dependent receptor]]
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