1txu: Difference between revisions

Revision as of 06:26, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1txu.png

Template:STRUCTURE 1txu

Crystal Structure of the Vps9 Domain of Rabex-5Crystal Structure of the Vps9 Domain of Rabex-5

Template:ABSTRACT PUBMED 15339665

About this StructureAbout this Structure

1TXU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5., Delprato A, Merithew E, Lambright DG, Cell. 2004 Sep 3;118(5):607-17. PMID:15339665

Page seeded by OCA on Tue Jul 29 06:26:19 2008

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OCA

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-'''Crystal Structure of the Vps9 Domain of Rabex-5'''
+===Crystal Structure of the Vps9 Domain of Rabex-5===
-==Overview==
+<!--
-The Rab5 GTPase, an essential regulator of endocytosis and endosome biogenesis, is activated by guanine-nucleotide exchange factors (GEFs) that contain a Vps9 domain. Here, we show that the catalytic core of the Rab GEF Rabex-5 has a tandem architecture consisting of a Vps9 domain stabilized by an indispensable helical bundle. A family-wide analysis of Rab specificity demonstrates high selectivity for Rab5 subfamily GTPases. Conserved exchange determinants map to a common surface of the Vps9 domain, which recognizes invariant aromatic residues in the switch regions of Rab GTPases and selects for the Rab5 subfamily by requiring a small nonacidic residue preceding a critical phenylalanine in the switch I region. These and other observations reveal unexpected similarity with the Arf exchange site in the Sec7 domain.
+The line below this paragraph, {{ABSTRACT_PUBMED_15339665}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_15339665}}
 ==About this Structure==
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 [[Category: Rab5 guanine-nucleotide exchange factor,gef]]
 [[Category: Vps9 domain]]
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