1u6h: Difference between revisions

Revision as of 06:12, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1u6h.png

Template:STRUCTURE 1u6h

Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879)Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879)

Template:ABSTRACT PUBMED 15642262

About this StructureAbout this Structure

1U6H is a Protein complex structure of sequences from Gallus gallus. Full crystallographic information is available from OCA.

ReferenceReference

A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head., Fillingham I, Gingras AR, Papagrigoriou E, Patel B, Emsley J, Critchley DR, Roberts GC, Barsukov IL, Structure. 2005 Jan;13(1):65-74. PMID:15642262

Page seeded by OCA on Tue Jul 29 06:12:11 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1u6h.gif|left|200px]]
+{{Seed}}
+[[Image:1u6h.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1u6h|  PDB=1u6h  |  SCENE=  }}
-'''Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879)'''
+===Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879)===
-==Overview==
+<!--
-The cytoskeletal protein talin plays a key role in activating integrins and in coupling them to the actin cytoskeleton. Its N-terminal globular head, which binds beta integrins, is linked to an extended rod having a C-terminal actin binding site and several vinculin binding sites (VBSs). The NMR structure of residues 755-889 of the rod (containing a VBS) is shown to be an amphipathic four-helix bundle with a left-handed topology. A talin peptide corresponding to the VBS binds the vinculin head; the X-ray crystallographic structure of this complex shows that the residues which interact with vinculin are buried in the hydrophobic core of the talin fragment. NMR shows that the interaction involves a major structural change in the talin fragment, including unfolding of one of its helices, making the VBS accessible to vinculin. Interestingly, the talin 755-889 fragment binds more than one vinculin head molecule, suggesting that the talin rod may contain additional as yet unrecognized VBSs.
+The line below this paragraph, {{ABSTRACT_PUBMED_15642262}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15642262 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15642262}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Roberts, G C.K.]]
 [[Category: Protein-protein complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:49:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:12:11 2008''