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| {{STRUCTURE_2j1o| PDB=2j1o | SCENE= }} | | {{STRUCTURE_2j1o| PDB=2j1o | SCENE= }} |
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| '''GERANYLGERANYL DIPHOSPHATE SYNTHASE FROM SINAPIS ALBA'''
| | ===GERANYLGERANYL DIPHOSPHATE SYNTHASE FROM SINAPIS ALBA=== |
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| ==Overview==
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| The crystal structure of the geranylgeranyl diphosphate synthase from Sinapis alba (mustard) has been solved in two crystal forms at 1.8 and 2.0 A resolutions. In one of these forms, the dimeric enzyme binds one molecule of the final product geranylgeranyl diphosphate in one subunit. The chainfold of the enzyme corresponds to that of other members of the farnesyl diphosphate synthase family. Whereas the binding modes of the two substrates dimethylallyl diphosphate and isopentenyl diphosphate at the allyl and isopentenyl sites, respectively, have been established with other members of the family, the complex structure presented reveals for the first time the binding mode of a reaction product at the isopentenyl site. The binding geometry of substrates and product in conjunction with the protein environment and the established chemistry of the reaction provide a clear picture of the reaction steps and atom displacements. Moreover, a comparison with a ligated homologous structure outlined an appreciable induced fit: helix alpha8 and its environment undergo a large conformational change when either the substrate dimethylallyl diphosphate or an analogue is bound to the allyl site; only a minor conformational change occurs when the other substrate isopentenyl diphosphate or the product is bound to the isopentenyl site. | | The line below this paragraph, {{ABSTRACT_PUBMED_17176041}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17176041 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17176041}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Transferase]] | | [[Category: Transferase]] |
| [[Category: Transit peptide]] | | [[Category: Transit peptide]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:13:09 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:52:33 2008'' |