1q8s: Difference between revisions

Revision as of 05:09, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1q8s.png

Template:STRUCTURE 1q8s

Pterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)ManPterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)Man

Template:ABSTRACT PUBMED 14729339

About this StructureAbout this Structure

1Q8S is a Single protein structure of sequence from Pterocarpus angolensis. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis of oligomannose recognition by the Pterocarpus angolensis seed lectin., Loris R, Van Walle I, De Greve H, Beeckmans S, Deboeck F, Wyns L, Bouckaert J, J Mol Biol. 2004 Jan 30;335(5):1227-40. PMID:14729339

Page seeded by OCA on Tue Jul 29 05:09:26 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1q8s.jpg|left|200px]]
+{{Seed}}
+[[Image:1q8s.png|left|200px]]
 <!--
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 {{STRUCTURE_1q8s|  PDB=1q8s  |  SCENE=  }}
-'''Pterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)Man'''
+===Pterocarpus angolensis lectin (PAL) in complex with the dimannoside Man(alpha1-6)Man===
-==Overview==
+<!--
-The crystal structure of a Man/Glc-specific lectin from the seeds of the bloodwood tree (Pterocarpus angolensis), a leguminous plant from central Africa, has been determined in complex with mannose and five manno-oligosaccharides. The lectin contains a classical mannose-specificity loop, but its metal-binding loop resembles that of lectins of unrelated specificity from Ulex europaeus and Maackia amurensis. As a consequence, the interactions with mannose in the primary binding site are conserved, but details of carbohydrate-binding outside the primary binding site differ from those seen in the equivalent carbohydrate complexes of concanavalin A. These observations explain the differences in their respective fine specificity profiles for oligomannoses. While Man(alpha1-3)Man and Man(alpha1-3)[Man(alpha1-6)]Man bind to PAL in low-energy conformations identical with that of ConA, Man(alpha1-6)Man is required to adopt a different conformation. Man(alpha1-2)Man can bind only in a single binding mode, in sharp contrast to ConA, which creates a higher affinity for this disaccharide by allowing two binding modes.
+The line below this paragraph, {{ABSTRACT_PUBMED_14729339}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14729339 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14729339}}
 ==About this Structure==
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 [[Category: Lectin]]
 [[Category: Mannose]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:00:28 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:09:26 2008''