2bc4: Difference between revisions

Revision as of 04:36, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2bc4.png

Template:STRUCTURE 2bc4

Crystal structure of HLA-DMCrystal structure of HLA-DM

Template:ABSTRACT PUBMED 16547258

About this StructureAbout this Structure

2BC4 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Small molecules that enhance the catalytic efficiency of HLA-DM., Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW, J Immunol. 2006 Apr 1;176(7):4208-20. PMID:16547258

Page seeded by OCA on Tue Jul 29 04:36:56 2008

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OCA

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-'''Crystal structure of HLA-DM'''
+===Crystal structure of HLA-DM===
-==Overview==
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-HLA-DM (DM) plays a critical role in Ag presentation to CD4 T cells by catalyzing the exchange of peptides bound to MHC class II molecules. Large lateral surfaces involved in the DM:HLA-DR (DR) interaction have been defined, but the mechanism of catalysis is not understood. In this study, we describe four small molecules that accelerate DM-catalyzed peptide exchange. Mechanistic studies demonstrate that these small molecules substantially enhance the catalytic efficiency of DM, indicating that they make the transition state of the DM:DR/peptide complex energetically more favorable. These compounds fall into two functional classes: two compounds are active only in the presence of DM, and binding data for one show a direct interaction with DM. The remaining two compounds have partial activity in the absence of DM, suggesting that they may act at the interface between DM and DR/peptide. A hydrophobic ridge in the DMbeta1 domain was implicated in the catalysis of peptide exchange because the activity of three of these enhancers was substantially reduced by point mutations in this area.
+The line below this paragraph, {{ABSTRACT_PUBMED_16547258}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_16547258}}
 ==About this Structure==
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 [[Category: Xing, X.]]
 [[Category: Mhc class ii]]
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