2bf1: Difference between revisions

Revision as of 04:19, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2bf1.png

Template:STRUCTURE 2bf1

STRUCTURE OF AN UNLIGANDED AND FULLY-GLYCOSYLATED SIV GP120 ENVELOPE GLYCOPROTEINSTRUCTURE OF AN UNLIGANDED AND FULLY-GLYCOSYLATED SIV GP120 ENVELOPE GLYCOPROTEIN

Template:ABSTRACT PUBMED 15729334

About this StructureAbout this Structure

2BF1 is a Single protein structure of sequence from Simian immunodeficiency virus. Full crystallographic information is available from OCA.

ReferenceReference

Structure of an unliganded simian immunodeficiency virus gp120 core., Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, Harrison SC, Nature. 2005 Feb 24;433(7028):834-41. PMID:15729334

Page seeded by OCA on Tue Jul 29 04:19:08 2008

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OCA

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-'''STRUCTURE OF AN UNLIGANDED AND FULLY-GLYCOSYLATED SIV GP120 ENVELOPE GLYCOPROTEIN'''
+===STRUCTURE OF AN UNLIGANDED AND FULLY-GLYCOSYLATED SIV GP120 ENVELOPE GLYCOPROTEIN===
-==Overview==
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-Envelope glycoproteins of human and simian immunodeficiency virus (HIV and SIV) undergo a series of conformational changes when they interact with receptor (CD4) and co-receptor on the surface of a potential host cell, leading ultimately to fusion of viral and cellular membranes. Structures of fragments of gp120 and gp41 from the envelope protein are known, in conformations corresponding to their post-attachment and postfusion states, respectively. We report the crystal structure, at 4 A resolution, of a fully glycosylated SIV gp120 core, in a conformation representing its prefusion state, before interaction with CD4. Parts of the protein have a markedly different organization than they do in the CD4-bound state. Comparison of the unliganded and CD4-bound structures leads to a model for events that accompany receptor engagement of an envelope glycoprotein trimer. The two conformations of gp120 also present distinct antigenic surfaces. We identify the binding site for a compound that inhibits viral entry.
+The line below this paragraph, {{ABSTRACT_PUBMED_15729334}}, adds the Publication Abstract to the page
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 [[Category: Gp120]]
 [[Category: Siv]]
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