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| {{STRUCTURE_1pdu| PDB=1pdu | SCENE= }} | | {{STRUCTURE_1pdu| PDB=1pdu | SCENE= }} |
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| '''Ligand-binding domain of Drosophila orphan nuclear receptor DHR38'''
| | ===Ligand-binding domain of Drosophila orphan nuclear receptor DHR38=== |
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| ==Overview==
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| Ecdysteroid pulses trigger the major developmental transitions during the Drosophila life cycle. These hormonal responses are thought to be mediated by the ecdysteroid receptor (EcR) and its heterodimeric partner Ultraspiracle (USP). We provide evidence for a second ecdysteroid signaling pathway mediated by DHR38, the Drosophila ortholog of the mammalian NGFI-B subfamily of orphan nuclear receptors. DHR38 also heterodimerizes with USP, and this complex responds to a distinct class of ecdysteroids in a manner that is independent of EcR. This response is unusual in that it does not involve direct binding of ecdysteroids to either DHR38 or USP. X-ray crystallographic analysis of DHR38 reveals the absence of both a classic ligand binding pocket and coactivator binding site, features that seem to be common to all NGFI-B subfamily members. Taken together, these data reveal the existence of a separate structural class of nuclear receptors that is conserved from fly to humans.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12809604}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12809604 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12809604}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Ligand-binding domain]] | | [[Category: Ligand-binding domain]] |
| [[Category: Nuclear receptor]] | | [[Category: Nuclear receptor]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:58:35 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:58:05 2008'' |