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| {{STRUCTURE_1r14| PDB=1r14 | SCENE= }} | | {{STRUCTURE_1r14| PDB=1r14 | SCENE= }} |
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| '''Carbohydrate recognition and neck domains of surfactant protein A (Sp-A) containing samarium'''
| | ===Carbohydrate recognition and neck domains of surfactant protein A (Sp-A) containing samarium=== |
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| ==Overview==
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| Surfactant protein A (SP-A), one of four proteins associated with pulmonary surfactant, binds with high affinity to alveolar phospholipid membranes, positioning the protein at the first line of defense against inhaled pathogens. SP-A exhibits both calcium-dependent carbohydrate binding, a characteristic of the collectin family, and specific interactions with lipid membrane components. The crystal structure of the trimeric carbohydrate recognition domain and neck domain of SP-A was solved to 2.1-A resolution with multiwavelength anomalous dispersion phasing from samarium. Two metal binding sites were identified, one in the highly conserved lectin site and the other 8.5 A away. The interdomain carbohydrate recognition domain-neck angle is significantly less in SP-A than in the homologous collectins, surfactant protein D, and mannose-binding protein. This conformational difference may endow the SP-A trimer with a more extensive hydrophobic surface capable of binding lipophilic membrane components. The appearance of this surface suggests a putative binding region for membrane-derived SP-A ligands such as phosphatidylcholine and lipid A, the endotoxic lipid component of bacterial lipopolysaccharide that mediates the potentially lethal effects of Gram-negative bacterial infection.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12913002}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12913002 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12913002}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Alpha helical neck region]] | | [[Category: Alpha helical neck region]] |
| [[Category: Crd]] | | [[Category: Crd]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:56:56 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:17:19 2008'' |