2fts: Difference between revisions

Revision as of 02:29, 29 July 2008

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File:2fts.png

Template:STRUCTURE 2fts

Crystal structure of the glycine receptor-gephyrin complexCrystal structure of the glycine receptor-gephyrin complex

Template:ABSTRACT PUBMED 16511563

About this StructureAbout this Structure

2FTS is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

Deciphering the structural framework of glycine receptor anchoring by gephyrin., Kim EY, Schrader N, Smolinsky B, Bedet C, Vannier C, Schwarz G, Schindelin H, EMBO J. 2006 Mar 22;25(6):1385-95. Epub 2006 Mar 2. PMID:16511563

Page seeded by OCA on Tue Jul 29 02:29:09 2008

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OCA

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-[[Image:2fts.gif|left|200px]]
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 {{STRUCTURE_2fts|  PDB=2fts  |  SCENE=  }}
-'''Crystal structure of the glycine receptor-gephyrin complex'''
+===Crystal structure of the glycine receptor-gephyrin complex===
-==Overview==
+<!--
-Glycine is the major inhibitory neurotransmitter in the spinal cord and brain stem. Gephyrin is required to achieve a high concentration of glycine receptors (GlyRs) in the postsynaptic membrane, which is crucial for efficient glycinergic signal transduction. The interaction between gephyrin and the GlyR involves the E-domain of gephyrin and a cytoplasmic loop located between transmembrane segments three and four of the GlyR beta subunit. Here, we present crystal structures of the gephyrin E-domain with and without the GlyR beta-loop at 2.4 and 2.7 A resolutions, respectively. The GlyR beta-loop is bound in a symmetric 'key and lock' fashion to each E-domain monomer in a pocket adjacent to the dimer interface. Structure-guided mutagenesis followed by in vitro binding and in vivo colocalization assays demonstrate that a hydrophobic interaction formed by Phe 330 of gephyrin and Phe 398 and Ile 400 of the GlyR beta-loop is crucial for binding.
+The line below this paragraph, {{ABSTRACT_PUBMED_16511563}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16511563 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16511563}}
 ==About this Structure==
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 [[Category: Glycine receptor]]
 [[Category: Neuroreceptor anchoring]]
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