2q5g: Difference between revisions

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{{STRUCTURE_2q5g|  PDB=2q5g  |  SCENE=  }}  
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'''Ligand binding domain of PPAR delta receptor in complex with a partial agonist'''
===Ligand binding domain of PPAR delta receptor in complex with a partial agonist===




==Overview==
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Structure based ligand design was used in order to design a partial agonist for the PPARdelta receptor. The maximum activation in the transactivation assay was reduced from 87% to 39%. The crystal structure of the ligand binding domain of the PPARdelta receptor in complex with compound 2 was determined in order to understand the structural changes which gave rise to the decrease in maximum activation.
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==About this Structure==
==About this Structure==
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[[Category: Ppar delta]]
[[Category: Ppar delta]]
[[Category: Transcription]]
[[Category: Transcription]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun  4 09:51:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:55:04 2008''

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