3bgl: Difference between revisions

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-[[Image:3bgl.jpg|left|200px]]
+{{Seed}}
+[[Image:3bgl.png|left|200px]]
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 {{STRUCTURE_3bgl|  PDB=3bgl  |  SCENE=  }}
-'''Hepatoselectivity of Statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors'''
+===Hepatoselectivity of Statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors===
-==Overview==
+<!--
--Sulfamoyl pyrroles were designed as novel hepatoselective HMG-CoA reductase inhibitors (statins) to reduce myalgia, a statin-induced adverse effect. The compounds were prepared via a [3+2] cycloaddition of a Munchnone with a sulfonamide-substituted alkyne. We identified compounds with greater selectivity for hepatocytes compared to L6-myocytes than rosuvastatin and atorvastatin. There was an inverse correlation of myocyte potencies and ClogP values. A number of analogs were effective at reducing cholesterol in acute and chronic in vivo models but they lacked sufficient chronic in vivo activity to warrant further development.
+The line below this paragraph, {{ABSTRACT_PUBMED_18155906}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18155906 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18155906}}
 ==Disease==
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 [[Category: Steroid biosynthesis]]
 [[Category: Transmembrane]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:38:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:49:47 2008''