2bid: Difference between revisions

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-[[Image:2bid.jpg|left|200px]]
+{{Seed}}
+[[Image:2bid.png|left|200px]]
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 {{STRUCTURE_2bid|  PDB=2bid  |  SCENE=  }}
-'''HUMAN PRO-APOPTOTIC PROTEIN BID'''
+===HUMAN PRO-APOPTOTIC PROTEIN BID===
-==Overview==
+<!--
-We report the solution structure of BID, an intracellular cross-talk agent that can amplify FAS/TNF apoptotic signal through the mitochondria death pathway after Caspase 8 cleavage. BID contains eight alpha helices where two central hydrophobic helices are surrounded by six amphipathic ones. The fold resembles poreforming bacterial toxins and shows similarity to BCL-XL although sequence homology to BCL-XL is limited to the 16-residue BH3 domain. Furthermore, we modeled a complex of BCL-XL and BID by aligning the BID and BAK BH3 motifs in the known BCL-XL-BAK BH3 complex. Additionally, we show that the overall structure of BID is preserved after cleavage by Caspase 8. We propose that BID has both BH3 domain-dependent and -independent modes of action in inducing mitochondrial damage.
+The line below this paragraph, {{ABSTRACT_PUBMED_10089877}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10089877 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10089877}}
 ==About this Structure==
-BID is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BID OCA].
+BID is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BID OCA].
 ==Reference==
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 [[Category: Apoptosis regulation and amplification]]
 [[Category: Programmed cell death]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:19:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:29:23 2008''