2pbh: Difference between revisions

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{{STRUCTURE_2pbh|  PDB=2pbh  |  SCENE=  }}  
{{STRUCTURE_2pbh|  PDB=2pbh  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 3.3 ANGSTROM RESOLUTION'''
===CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 3.3 ANGSTROM RESOLUTION===




==Overview==
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A wild-type human procathepsin B was expressed, crystallized in two crystal forms and its crystal structure determined at 3.2 and 3.3 Angstroms resolution. The structure reveals that the propeptide folds on the cathepsin B surface, shielding the enzyme active site from exposure to solvent. The structure of the enzymatically active domains is virtually identical to that of the native enzyme [Musil et al. (1991) EMBO J. 10, 2321-2330]: the main difference is that the occluding loop residues are lifted above the body of the mature enzyme, supporting the propeptide structure.
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{{ABSTRACT_PUBMED_8617355}}


==About this Structure==
==About this Structure==
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[[Category: Proenzyme]]
[[Category: Proenzyme]]
[[Category: Thiol protease]]
[[Category: Thiol protease]]
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Revision as of 00:18, 29 July 2008

File:2pbh.gif

Template:STRUCTURE 2pbh

CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 3.3 ANGSTROM RESOLUTIONCRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 3.3 ANGSTROM RESOLUTION

Template:ABSTRACT PUBMED 8617355

About this StructureAbout this Structure

2PBH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide., Turk D, Podobnik M, Kuhelj R, Dolinar M, Turk V, FEBS Lett. 1996 Apr 22;384(3):211-4. PMID:8617355

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