2b5n: Difference between revisions

Revision as of 23:56, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2b5n.png

Template:STRUCTURE 2b5n

Crystal Structure of the DDB1 BPB DomainCrystal Structure of the DDB1 BPB Domain

Template:ABSTRACT PUBMED 16413485

About this StructureAbout this Structure

2B5N is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase., Li T, Chen X, Garbutt KC, Zhou P, Zheng N, Cell. 2006 Jan 13;124(1):105-17. PMID:16413485

Page seeded by OCA on Mon Jul 28 23:56:47 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2b5n.gif|left|200px]]
+{{Seed}}
+[[Image:2b5n.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2b5n|  PDB=2b5n  |  SCENE=  }}
-'''Crystal Structure of the DDB1 BPB Domain'''
+===Crystal Structure of the DDB1 BPB Domain===
-==Overview==
+<!--
-The DDB1-Cul4A ubiquitin ligase complex promotes protein ubiquitination in diverse cellular functions and is reprogrammed by the V proteins of paramyxoviruses to degrade STATs and block interferon signaling. Here we report the crystal structures of DDB1 alone and in complex with the simian virus 5 V protein. The DDB1 structure reveals an intertwined three-propeller cluster, which contains two tightly coupled beta propellers with a large pocket in between and a third beta propeller flexibly attached on the side. The rigid double-propeller fold of DDB1 is targeted by the viral V protein, which inserts an entire helix into the double-propeller pocket, whereas the third propeller domain docks DDB1 to the N terminus of the Cul4A scaffold. Together, these results not only provide structural insights into how the virus hijacks the DDB1-Cul4A ubiquitin ligase but also establish a structural framework for understanding the multiple functions of DDB1 in the uniquely assembled cullin-RING E3 machinery.
+The line below this paragraph, {{ABSTRACT_PUBMED_16413485}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16413485 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16413485}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Ddb1]]
 [[Category: Propeller cluster]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:53:10 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:56:47 2008''