1z3s: Difference between revisions

Revision as of 22:00, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1z3s.png

Template:STRUCTURE 1z3s

Angiopoietin-2 Receptor Binding DomainAngiopoietin-2 Receptor Binding Domain

Template:ABSTRACT PUBMED 15893672

About this StructureAbout this Structure

1Z3S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition., Barton WA, Tzvetkova D, Nikolov DB, Structure. 2005 May;13(5):825-32. PMID:15893672

Page seeded by OCA on Mon Jul 28 22:00:42 2008

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OCA

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-'''Angiopoietin-2 Receptor Binding Domain'''
+===Angiopoietin-2 Receptor Binding Domain===
-==Overview==
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-The angiopoietins comprise a small class of secreted glycoproteins that play crucial roles in the maturation and maintenance of the mammalian vascular and lymphatic systems. They exert their effects through a member of the tyrosine kinase receptor family, Tie2. Angiopoietin/Tie2 signaling is unique among tyrosine kinase receptor-ligand systems in that distinct angiopoietin ligands, although highly homologous, can function as agonists or antagonists in a context-dependent manner. In an effort to understand this molecular dichotomy, we have crystallized and determined the 2.4 A crystal structure of the Angiopoietin-2 (Ang2) receptor binding region. The structure reveals a fibrinogen fold with a unique C-terminal P domain. Conservation analysis and structure-based mutagenesis identify a groove on the Ang2 molecular surface that mediates receptor recognition.
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 ==About this Structure==
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 [[Category: Angiogenesis]]
 [[Category: Tie2 binding]]
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