2nxz: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
[[Image:2nxz.gif|left|200px]]
{{Seed}}
[[Image:2nxz.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2nxz|  PDB=2nxz  |  SCENE=  }}  
{{STRUCTURE_2nxz|  PDB=2nxz  |  SCENE=  }}  


'''HIV-1 gp120 Envelope Glycoprotein (T257S, S334A, S375W) Complexed with CD4 and Antibody 17b'''
===HIV-1 gp120 Envelope Glycoprotein (T257S, S334A, S375W) Complexed with CD4 and Antibody 17b===




==Overview==
<!--
The remarkable diversity, glycosylation and conformational flexibility of the human immunodeficiency virus type 1 (HIV-1) envelope (Env), including substantial rearrangement of the gp120 glycoprotein upon binding the CD4 receptor, allow it to evade antibody-mediated neutralization. Despite this complexity, the HIV-1 Env must retain conserved determinants that mediate CD4 binding. To evaluate how these determinants might provide opportunities for antibody recognition, we created variants of gp120 stabilized in the CD4-bound state, assessed binding of CD4 and of receptor-binding-site antibodies, and determined the structure at 2.3 A resolution of the broadly neutralizing antibody b12 in complex with gp120. b12 binds to a conformationally invariant surface that overlaps a distinct subset of the CD4-binding site. This surface is involved in the metastable attachment of CD4, before the gp120 rearrangement required for stable engagement. A site of vulnerability, related to a functional requirement for efficient association with CD4, can therefore be targeted by antibody to neutralize HIV-1.
The line below this paragraph, {{ABSTRACT_PUBMED_17301785}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17301785 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17301785}}
 
==Disease==
Known disease associated with this structure: CD4  lymphocyte deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]], Lupus erythematosus, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]]


==About this Structure==
==About this Structure==
Line 43: Line 50:
[[Category: Gp120]]
[[Category: Gp120]]
[[Category: Hiv]]
[[Category: Hiv]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:03:23 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:56:00 2008''

Revision as of 21:56, 28 July 2008

File:2nxz.png

Template:STRUCTURE 2nxz

HIV-1 gp120 Envelope Glycoprotein (T257S, S334A, S375W) Complexed with CD4 and Antibody 17bHIV-1 gp120 Envelope Glycoprotein (T257S, S334A, S375W) Complexed with CD4 and Antibody 17b

Template:ABSTRACT PUBMED 17301785

DiseaseDisease

Known disease associated with this structure: CD4 lymphocyte deficiency OMIM:[186940], Lupus erythematosus, susceptibility to OMIM:[186940]

About this StructureAbout this Structure

2NXZ is a Single protein structure of sequence from Homo sapiens and Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

ReferenceReference

Structural definition of a conserved neutralization epitope on HIV-1 gp120., Zhou T, Xu L, Dey B, Hessell AJ, Van Ryk D, Xiang SH, Yang X, Zhang MY, Zwick MB, Arthos J, Burton DR, Dimitrov DS, Sodroski J, Wyatt R, Nabel GJ, Kwong PD, Nature. 2007 Feb 15;445(7129):732-7. PMID:17301785

Page seeded by OCA on Mon Jul 28 21:56:00 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2nxz&oldid=717007"