1xdt: Difference between revisions

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-[[Image:1xdt.gif|left|200px]]
+{{Seed}}
+[[Image:1xdt.png|left|200px]]
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 {{STRUCTURE_1xdt|  PDB=1xdt  |  SCENE=  }}
-'''COMPLEX OF DIPHTHERIA TOXIN AND HEPARIN-BINDING EPIDERMAL GROWTH FACTOR'''
+===COMPLEX OF DIPHTHERIA TOXIN AND HEPARIN-BINDING EPIDERMAL GROWTH FACTOR===
-==Overview==
+<!--
-We describe the crystal structure at 2.65 A resolution of diphtheria toxin (DT) complexed 1:1 with a fragment of its cell-surface receptor, the precursor of heparin-binding epidermal-growth-factor-like growth factor (HBEGF). HBEGF in the complex has the typical EGF-like fold and packs its principal beta hairpin against the face of a beta sheet in the receptor-binding domain of DT. The interface has a predominantly hydrophobic core, and polar interactions are formed at the periphery. The structure of the complex suggests that part of the membrane anchor of the receptor can interact with a hinge region of DT. The toxin molecule is thereby induced to form an open conformation conducive to membrane insertion. The structure provides a basis for altering the binding specificity of the toxin, and may also serve as a model for other EGF-receptor interactions.
+The line below this paragraph, {{ABSTRACT_PUBMED_9659904}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9659904 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9659904}}
 ==About this Structure==
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 [[Category: Heparin-binding epidermal growth factor]]
 [[Category: Receptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:53:59 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:22:26 2008''