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| [[Image:2fxu.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2fxu| PDB=2fxu | SCENE= }} | | {{STRUCTURE_2fxu| PDB=2fxu | SCENE= }} |
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| '''X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.'''
| | ===X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.=== |
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| ==Overview==
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| Bistramide A is a highly potent antiproliferative marine natural product from Lissoclinum bistratum. We have previously established actin as the primary cellular receptor of bistramide A. We report herein the X-ray structure of bistramide A bound to monomeric actin at a resolution of 1.35 A. The most notable aspect of the bistramide A-actin structure is an extensive hydrogen-bonding network established upon a deep penetration of the central segment of bistramide A into the actin-binding cleft between subdomains 1 and 3. The structure presents the first insight into the observed ability of bistramide A to modulate G-actin polymerization. The structural information combined with our ability to chemically modify the bistramide framework provides the basis for rational development of a series of new synthetic analogues as useful probes for studying actin cytoskeleton and as potential therapeutic leads.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16551075}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16551075 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16551075}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Tereshko, V.]] | | [[Category: Tereshko, V.]] |
| [[Category: Actin complexed to bistramide some]] | | [[Category: Actin complexed to bistramide some]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:25:47 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:05:51 2008'' |