1xfe: Difference between revisions

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[[Image:1xfe.gif|left|200px]]
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{{STRUCTURE_1xfe|  PDB=1xfe  |  SCENE=  }}  
{{STRUCTURE_1xfe|  PDB=1xfe  |  SCENE=  }}  


'''Solution structure of the LA7-EGFA pair from the LDL receptor'''
===Solution structure of the LA7-EGFA pair from the LDL receptor===




==Overview==
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Low-density lipoprotein (LDL) receptors bind lipoprotein particles at the cell surface and release them in the low pH environment of the endosome. The published structure of the receptor determined at endosomal pH reveals an interdomain interface between its beta propeller and its fourth and fifth ligand binding (LA) repeats, suggesting that the receptor adopts a closed conformation at low pH to release LDL. Here, we combine lipoprotein binding and release assays with NMR spectroscopy to examine structural features of the receptor promoting release of LDL at low pH. These studies lead to a model in which the receptor uses a pH-invariant scaffold as an anchor to restrict conformational search space, combining it with flexible linkers between ligand binding repeats to interconvert between open and closed conformations. This finely tuned balance between interdomain rigidity and flexibility is likely to represent a shared structural feature in proteins of the LDL receptor family.
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{{ABSTRACT_PUBMED_15494314}}


==Disease==
==Disease==
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==About this Structure==
==About this Structure==
1XFE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFE OCA].  
1XFE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFE OCA].  


==Reference==
==Reference==
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[[Category: Egf-like repeat]]
[[Category: Egf-like repeat]]
[[Category: Ligand-binding repeat]]
[[Category: Ligand-binding repeat]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:57:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:53:49 2008''

Revision as of 20:53, 28 July 2008

File:1xfe.png

Template:STRUCTURE 1xfe

Solution structure of the LA7-EGFA pair from the LDL receptorSolution structure of the LA7-EGFA pair from the LDL receptor

Template:ABSTRACT PUBMED 15494314

DiseaseDisease

Known disease associated with this structure: Hypercholesterolemia, familial OMIM:[606945]

About this StructureAbout this Structure

1XFE is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

ReferenceReference

Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor., Beglova N, Jeon H, Fisher C, Blacklow SC, Mol Cell. 2004 Oct 22;16(2):281-92. PMID:15494314

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