1n99: Difference between revisions

Revision as of 20:34, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1n99.png

Template:STRUCTURE 1n99

CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENINCRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN

Template:ABSTRACT PUBMED 12679023

About this StructureAbout this Structure

1N99 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

PDZ tandem of human syntenin: crystal structure and functional properties., Kang BS, Cooper DR, Jelen F, Devedjiev Y, Derewenda U, Dauter Z, Otlewski J, Derewenda ZS, Structure. 2003 Apr;11(4):459-68. PMID:12679023

Page seeded by OCA on Mon Jul 28 20:34:46 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1n99.gif|left|200px]]
+{{Seed}}
+[[Image:1n99.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1n99|  PDB=1n99  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN'''
+===CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN===
-==Overview==
+<!--
-Syntenin, a 33 kDa protein, interacts with several cell membrane receptors and with merlin, the product of the causal gene for neurofibromatosis type II. We report a crystal structure of the functional fragment of human syntenin containing two canonical PDZ domains, as well as binding studies for full-length syntenin, the PDZ tandem, and isolated PDZ domains. We show that the functional properties of syntenin are a result of independent interactions with target peptides, and that each domain is able to bind peptides belonging to two different classes: PDZ1 binds peptides from classes I and III, while PDZ2 interacts with classes I and II. The independent binding of merlin by PDZ1 and syndecan-4 by PDZ2 provides direct evidence for the coupling of syndecan-mediated signaling to actin regulation by merlin.
+The line below this paragraph, {{ABSTRACT_PUBMED_12679023}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12679023 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12679023}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Otlewski, J.]]
 [[Category: Pdz domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:15:16 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:34:46 2008''