2gm1: Difference between revisions

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-[[Image:2gm1.gif|left|200px]]
+{{Seed}}
+[[Image:2gm1.png|left|200px]]
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 {{STRUCTURE_2gm1|  PDB=2gm1  |  SCENE=  }}
-'''Crystal structure of the mitotic kinesin eg5 in complex with mg-adp and n-(3-aminopropyl)-n-((3-benzyl-5-chloro-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)(cyclopropyl)methyl)-4-methylbenzamide'''
+===Crystal structure of the mitotic kinesin eg5 in complex with mg-adp and n-(3-aminopropyl)-n-((3-benzyl-5-chloro-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)(cyclopropyl)methyl)-4-methylbenzamide===
-==Overview==
+<!--
-Synthesis and SAR of substituted pyrrolotriazine-4-one analogues as Eg5 inhibitors are described. Many of these analogues displayed potent inhibitory activities in the Eg5 ATPase and A2780 cell proliferation assays. In addition, pyrrolotriazine-4-one analogue 26 demonstrated in vivo efficacy in an iv P388 murine leukemia model. Both NMR and X-ray crystallographic studies revealed that these analogues bind to an allosteric site on the Eg5 protein.
+The line below this paragraph, {{ABSTRACT_PUBMED_16730979}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16730979 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16730979}}
 ==About this Structure==
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 [[Category: Sheriff, S.]]
 [[Category: Eg5 mg-adp complex inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:15:27 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:26:13 2008''