2q7o: Difference between revisions

Revision as of 19:57, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2q7o.png

Template:STRUCTURE 2q7o

Structure of human purine nucleoside phosphorylase in complex with L-Immucillin-HStructure of human purine nucleoside phosphorylase in complex with L-Immucillin-H

Template:ABSTRACT PUBMED 18154341

About this StructureAbout this Structure

2Q7O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase., Rinaldo-Matthis A, Murkin AS, Ramagopal UA, Clinch K, Mee SP, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL, J Am Chem Soc. 2008 Jan 23;130(3):842-4. Epub 2007 Dec 23. PMID:18154341

Page seeded by OCA on Mon Jul 28 19:56:58 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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+===Structure of human purine nucleoside phosphorylase in complex with L-Immucillin-H===
-==Overview==
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-Human purine nucleoside phosphorylase (PNP) was crystallized with transition-state analogue inhibitors Immucillin-H and DADMe-Immucillin-H synthesized with ribosyl mimics of l-stereochemistry. The inhibitors demonstrate that major driving forces for tight binding of these analogues are the leaving group interaction and the cationic mimicry of the transition state, even though large geometric changes occur with d-Immucillins and l-Immucillins bound to human PNP.
+The line below this paragraph, {{ABSTRACT_PUBMED_18154341}}, adds the Publication Abstract to the page
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 ==About this Structure==
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 [[Category: Purine nucleoside phosphorylase]]
 [[Category: Transferase]]
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