2qac: Difference between revisions

Revision as of 19:31, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2qac.png

Template:STRUCTURE 2qac

The closed MTIP-MyosinA-tail complex from the malaria parasite invasion machineryThe closed MTIP-MyosinA-tail complex from the malaria parasite invasion machinery

Template:ABSTRACT PUBMED 17628590

About this StructureAbout this Structure

2QAC is a Protein complex structure of sequences from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.

ReferenceReference

The closed MTIP-myosin A-tail complex from the malaria parasite invasion machinery., Bosch J, Turley S, Roach CM, Daly TM, Bergman LW, Hol WG, J Mol Biol. 2007 Sep 7;372(1):77-88. Epub 2007 Jun 9. PMID:17628590

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''The closed MTIP-MyosinA-tail complex from the malaria parasite invasion machinery'''
+===The closed MTIP-MyosinA-tail complex from the malaria parasite invasion machinery===
-==Overview==
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-The Myosin A-tail interacting protein (MTIP) of the malaria parasite links the actomyosin motor of the host cell invasion machinery to its inner membrane complex. We report here that at neutral pH Plasmodium falciparum MTIP in complex with Myosin A adopts a compact conformation, with its two domains completely surrounding the Myosin A-tail helix, dramatically different from previously observed extended MTIP structures. Crystallographic and mutagenesis studies show that H810 and K813 of Myosin A are key players in the formation of the compact MTIP:Myosin A complex. Only the unprotonated state of Myosin A-H810 is compatible with the compact complex. Most surprisingly, every side-chain atom of Myosin A-K813 is engaged in contacts with MTIP. While this side-chain was previously considered to prevent a compact conformation of MTIP with Myosin A, it actually appears to be essential for the formation of the compact complex. The hydrophobic pockets and adaptability seen in the available series of MTIP structures bodes well for the discovery of inhibitors of cell invasion by malaria parasites.
+The line below this paragraph, {{ABSTRACT_PUBMED_17628590}}, adds the Publication Abstract to the page
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 [[Category: Structural genomic]]
 [[Category: Structural genomics of pathogenic protozoa consortium]]
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