2uw9: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:2uw9.gif|left|200px]]
+{{Seed}}
+[[Image:2uw9.png|left|200px]]
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 {{STRUCTURE_2uw9|  PDB=2uw9  |  SCENE=  }}
-'''STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH 4-(4-CHLORO-PHENYL)-4-(4-(1H-PYRAZOL-4-YL)-PHENYL)-PIPERIDINE'''
+===STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH 4-(4-CHLORO-PHENYL)-4-(4-(1H-PYRAZOL-4-YL)-PHENYL)-PIPERIDINE===
-==Overview==
+<!--
-Using fragment-based screening techniques, 5-methyl-4-phenyl-1H-pyrazole (IC50 80 microM) was identified as a novel, low molecular weight inhibitor of protein kinase B (PKB). Herein we describe the rapid elaboration of highly potent and ligand efficient analogues using a fragment growing approach. Iterative structure-based design was supported by protein-ligand structure determinations using a PKA-PKB "chimera" and a final protein-ligand structure of a lead compound in PKBbeta itself.
+The line below this paragraph, {{ABSTRACT_PUBMED_17451234}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17451234 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17451234}}
 ==About this Structure==
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 [[Category: Transferase/inhibitor complex]]
 [[Category: Wnt signaling pathway]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:33:23 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:11:31 2008''