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| {{STRUCTURE_1xr7| PDB=1xr7 | SCENE= }} | | {{STRUCTURE_1xr7| PDB=1xr7 | SCENE= }} |
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| '''Crystal structure of RNA-dependent RNA Polymerase 3D from human rhinovirus serotype 16'''
| | ===Crystal structure of RNA-dependent RNA Polymerase 3D from human rhinovirus serotype 16=== |
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| ==Overview==
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| Human rhinoviruses (HRV), the predominant members of the Picornaviridae family of positive-strand RNA viruses, are the major causative agents of the common cold. Given the lack of effective treatments for rhinoviral infections, virally encoded proteins have become attractive therapeutic targets. The HRV genome encodes an RNA-dependent RNA polymerase (RdRp) denoted 3Dpol, which is responsible for replicating the viral genome and for synthesizing a protein primer used in the replication. Here the crystal structures for three viral serotypes (1B, 14, and 16) of HRV 3Dpol have been determined. The three structures are very similar to one another, and to the closely related poliovirus (PV) 3Dpol enzyme. Because the reported PV crystal structure shows significant disorder, HRV 3Dpol provides the first complete view of a picornaviral RdRp. The folding topology of HRV 3Dpol also resembles that of RdRps from hepatitis C virus (HCV) and rabbit hemorrhagic disease virus (RHDV) despite very low sequence homology.
| | The line below this paragraph, {{ABSTRACT_PUBMED_15296746}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15296746 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15296746}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Yu, X.]] | | [[Category: Yu, X.]] |
| [[Category: Rna-dependent rna polymerase]] | | [[Category: Rna-dependent rna polymerase]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:24:10 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:02:48 2008'' |