1vz3: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1vz3.jpg|left|200px]]
+{{Seed}}
+[[Image:1vz3.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1vz3|  PDB=1vz3  |  SCENE=  }}
-'''PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, T597C MUTANT'''
+===PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, T597C MUTANT===
-==Overview==
+<!--
-Prolyl oligopeptidase contains a peptidase domain and its catalytic triad is covered by the central tunnel of a seven-bladed beta-propeller. This domain makes the enzyme an oligopeptidase by excluding large structured peptides from the active site. The apparently rigid crystal structure does not explain how the substrate can approach the catalytic groups. Two possibilities of substrate access were investigated: either blades 1 and 7 of the propeller domain move apart, or the peptidase and/or propeller domains move to create an entry site at the domain interface. Engineering disulfide bridges to the expected oscillating structures prevented such movements, which destroyed the catalytic activity and precluded substrate binding. This indicated that concerted movements of the propeller and the peptidase domains are essential for the enzyme action.
+The line below this paragraph, {{ABSTRACT_PUBMED_15210359}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15210359 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15210359}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Prolyl oligopeptidase]]
 [[Category: Serine protease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:56:24 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:44:00 2008''