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-[[Image:2bed.gif|left|200px]]
+{{Seed}}
+[[Image:2bed.png|left|200px]]
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 {{STRUCTURE_2bed|  PDB=2bed  |  SCENE=  }}
-'''Structure of FPT bound to inhibitor SCH207736'''
+===Structure of FPT bound to inhibitor SCH207736===
-==Overview==
+<!--
-Benzocycloheptapyridine tricyclic compounds with piperazine or substituted piperidine moieties extending either from the 5- or 6-position of the tricyclic bridgehead exhibited enhanced FTase activity: this resulted from favorable binding of the ligand nitrogen with the catalytic zinc found in the FTase. A single isomer at C-11 with piperazine adduct extending from the 6-position, compound 24, exhibited excellent FTase activity with IC50 = 0.007 microM, soft agar IC50 = 72 nM, and Rat AUC(PO, 10 mpk) = 4.0 microM x h. X-ray of (-)-[8-chloro-6-(1-piperazinyl)-1H-benzo[5,6]]cyclohepta[1,2-b]pyridine-11 -yl]-1-(methylsulfonyl)piperidine 24 bound to Ftase revealed favorable interaction between piperazine nitrogen and catalytic zinc atom.
+The line below this paragraph, {{ABSTRACT_PUBMED_16298128}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16298128 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16298128}}
 ==About this Structure==
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 [[Category: Fpt]]
 [[Category: Ptase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:10:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:40:01 2008''