1zml: Difference between revisions

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{{STRUCTURE_1zml|  PDB=1zml  |  SCENE=  }}  
{{STRUCTURE_1zml|  PDB=1zml  |  SCENE=  }}  


'''Crystal Structure of the Catalytic Domain of Factor XI in complex with (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)phenethyl)guanidine'''
===Crystal Structure of the Catalytic Domain of Factor XI in complex with (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)phenethyl)guanidine===




==Overview==
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A series of functionalized aryl boronic acids were synthesized and evaluated as potential inhibitors of factor XIa. Crystal structures of the protein-inhibitor complexes led to the design and synthesis of second generation compounds showing single digit micromolar inhibition against FXIa and selectivity against thrombin, trypsin, and FXa.
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{{ABSTRACT_PUBMED_16876411}}


==Disease==
==Disease==
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[[Category: Fxi]]
[[Category: Fxi]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:48:50 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:48:15 2008''

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