2a91: Difference between revisions

Revision as of 17:23, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2a91.png

Template:STRUCTURE 2a91

Crystal structure of ErbB2 domains 1-3Crystal structure of ErbB2 domains 1-3

Template:ABSTRACT PUBMED 12620236

About this StructureAbout this Structure

2A91 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors., Garrett TP, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Kofler M, Jorissen RN, Nice EC, Burgess AW, Ward CW, Mol Cell. 2003 Feb;11(2):495-505. PMID:12620236

Page seeded by OCA on Mon Jul 28 17:23:39 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 {{STRUCTURE_2a91|  PDB=2a91  |  SCENE=  }}
-'''Crystal structure of ErbB2 domains 1-3'''
+===Crystal structure of ErbB2 domains 1-3===
-==Overview==
+<!--
-ErbB2 does not bind ligand, yet appears to be the major signaling partner for other ErbB receptors by forming heteromeric complexes with ErbB1, ErbB3, or ErbB4. The crystal structure of residues 1-509 of ErbB2 at 2.5 A resolution reveals an activated conformation similar to that of the EGFR when complexed with ligand and very different from that seen in the unactivated forms of ErbB3 or EGFR. The structure explains the inability of ErbB2 to bind known ligands and suggests why ErbB2 fails to form homodimers. Together, the data suggest a model in which ErbB2 is already in the activated conformation and ready to interact with other ligand-activated ErbB receptors.
+The line below this paragraph, {{ABSTRACT_PUBMED_12620236}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_12620236}}
 ==About this Structure==
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 [[Category: Cell-surface receptor]]
 [[Category: Tyrosine kinase receptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:45:46 2008''
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