1s4f: Difference between revisions

Revision as of 17:17, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1s4f.png

Template:STRUCTURE 1s4f

Crystal Structure of RNA-dependent RNA polymerase construct 2 from bovine viral diarrhea virus (BVDV)Crystal Structure of RNA-dependent RNA polymerase construct 2 from bovine viral diarrhea virus (BVDV)

Template:ABSTRACT PUBMED 15070734

About this StructureAbout this Structure

1S4F is a Single protein structure of sequence from Bovine viral diarrhea virus 1. Full crystallographic information is available from OCA.

ReferenceReference

The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation., Choi KH, Groarke JM, Young DC, Kuhn RJ, Smith JL, Pevear DC, Rossmann MG, Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4425-30. Epub 2004 Mar 19. PMID:15070734

Page seeded by OCA on Mon Jul 28 17:17:10 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1s4f.jpg|left|200px]]
+{{Seed}}
+[[Image:1s4f.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1s4f|  PDB=1s4f  |  SCENE=  }}
-'''Crystal Structure of RNA-dependent RNA polymerase construct 2 from bovine viral diarrhea virus (BVDV)'''
+===Crystal Structure of RNA-dependent RNA polymerase construct 2 from bovine viral diarrhea virus (BVDV)===
-==Overview==
+<!--
-The bovine viral diarrhea virus (BVDV) RNA-dependent RNA polymerase can initiate RNA replication by a de novo mechanism without a primer. The structure of BVDV polymerase, determined to 2.9-A resolution, contains a unique N-terminal domain, in addition to the fingers, palm, and thumb domains common to other polymerases. The structure of BVDV polymerase complexed with GTP, which is required for de novo (primer-independent) initiation, shows that GTP binds adjacent to the initiation NTP, suggesting that the GTP mimics a vestigial RNA product. Comparison of five monomers in two different crystal forms showed conformational changes in the fingertip region and in the thumb domain that may help to translocate the RNA template and product strands during elongation. The putative binding sites of previously reported BVDV inhibitors are also discussed.
+The line below this paragraph, {{ABSTRACT_PUBMED_15070734}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15070734 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15070734}}
 ==About this Structure==
@@ Line 35: / Line 39: @@
 [[Category: Primer independent initiation]]
 [[Category: Rna synthesis]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:17:02 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:17:10 2008''