2o5k: Difference between revisions

Revision as of 17:11, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2o5k.png

Template:STRUCTURE 2o5k

Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitorCrystal Structure of GSK3beta in complex with a benzoimidazol inhibitor

Template:ABSTRACT PUBMED 17764934

About this StructureAbout this Structure

2O5K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3beta., Shin D, Lee SC, Heo YS, Lee WY, Cho YS, Kim YE, Hyun YL, Cho JM, Lee YS, Ro S, Bioorg Med Chem Lett. 2007 Oct 15;17(20):5686-9. Epub 2007 Aug 19. PMID:17764934

Page seeded by OCA on Mon Jul 28 17:11:39 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2o5k.jpg|left|200px]]
+{{Seed}}
+[[Image:2o5k.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2o5k|  PDB=2o5k  |  SCENE=  }}
-'''Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitor'''
+===Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitor===
-==Overview==
+<!--
-A hydroxy functional group was introduced as the hydrogen bond donor and acceptor at the hinge region of protein kinase in order to develop novel ATP-competitive inhibitors. Several derivatives of 7-hydroxyl-1H-benzoimidazole were designed as inhibitors of glycogen synthase kinase-3beta with the help of ab initio calculations and a docking study. Enzymatic assay and an X-ray complex study showed that these designed compounds were highly potent ATP-competitive inhibitors.
+The line below this paragraph, {{ABSTRACT_PUBMED_17764934}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17764934 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17764934}}
 ==About this Structure==
@@ Line 34: / Line 38: @@
 [[Category: Gsk3beta]]
 [[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:21:17 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:11:39 2008''