2boc: Difference between revisions

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-[[Image:2boc.gif|left|200px]]
+{{Seed}}
+[[Image:2boc.png|left|200px]]
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 {{STRUCTURE_2boc|  PDB=2boc  |  SCENE=  }}
-'''POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRAETHYLARSONIUM (TEAS)'''
+===POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRAETHYLARSONIUM (TEAS)===
-==Overview==
+<!--
-Potassium channels catalyze the selective transfer of potassium across the cell membrane and are essential for setting the resting potential in cells, controlling heart rate and modulating the firing pattern in neurons. Tetraethylammonium (TEA) blocks ion conduction through potassium channels in a voltage-dependent manner from both sides of the membrane. Here we show the structural basis of TEA blockade by cocrystallizing the prokaryotic potassium channel KcsA with two selective TEA analogs. TEA binding at both sites alters ion occupancy in the selectivity filter; these findings underlie the mutual destabilization and voltage-dependence of TEA blockade. We propose that TEA blocks potassium channels by acting as a potassium analog at the dehydration transition step during permeation.
+The line below this paragraph, {{ABSTRACT_PUBMED_15852022}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15852022 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_15852022}}
 ==About this Structure==
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 [[Category: Potassium channel]]
 [[Category: Protein-antibody fab complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:34:10 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:08:35 2008''