1n94: Difference between revisions

Revision as of 17:00, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1n94.png

Template:STRUCTURE 1n94

Aryl Tetrahydropyridine Inhbitors of Farnesyltransferase: Glycine, Phenylalanine and Histidine DerivatesAryl Tetrahydropyridine Inhbitors of Farnesyltransferase: Glycine, Phenylalanine and Histidine Derivates

Template:ABSTRACT PUBMED 12657282

About this StructureAbout this Structure

1N94 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives., Gwaltney SL 2nd, O'Connor SJ, Nelson LT, Sullivan GM, Imade H, Wang W, Hasvold L, Li Q, Cohen J, Gu WZ, Tahir SK, Bauch J, Marsh K, Ng SC, Frost DJ, Zhang H, Muchmore S, Jakob CG, Stoll V, Hutchins C, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2003 Apr 7;13(7):1359-62. PMID:12657282

Page seeded by OCA on Mon Jul 28 17:00:08 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1n94.gif|left|200px]]
+{{Seed}}
+[[Image:1n94.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1n94|  PDB=1n94  |  SCENE=  }}
-'''Aryl Tetrahydropyridine Inhbitors of Farnesyltransferase: Glycine, Phenylalanine and Histidine Derivates'''
+===Aryl Tetrahydropyridine Inhbitors of Farnesyltransferase: Glycine, Phenylalanine and Histidine Derivates===
-==Overview==
+<!--
-Inhibitors of farnesyltransferase are effective against a variety of tumors in mouse models of cancer. Clinical trials to evaluate these agents in humans are ongoing. In our effort to develop new farnesyltransferase inhibitors, we have discovered a series of aryl tetrahydropyridines that incorporate substituted glycine, phenylalanine and histidine residues. The design, synthesis, SAR and biological properties of these compounds will be discussed.
+The line below this paragraph, {{ABSTRACT_PUBMED_12657282}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12657282 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12657282}}
 ==About this Structure==
@@ Line 34: / Line 38: @@
 [[Category: Farnesyltransferase]]
 [[Category: Prenyltransferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:14:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:00:08 2008''