2p3t: Difference between revisions

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-[[Image:2p3t.jpg|left|200px]]
+{{Seed}}
+[[Image:2p3t.png|left|200px]]
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 {{STRUCTURE_2p3t|  PDB=2p3t  |  SCENE=  }}
-'''Crystal structure of human factor XA complexed with 3-Chloro-4-(2-methylamino-imidazol-1-ylmethyl)-thiophene-2-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-6-methoxy-phenyl]-amide'''
+===Crystal structure of human factor XA complexed with 3-Chloro-4-(2-methylamino-imidazol-1-ylmethyl)-thiophene-2-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-6-methoxy-phenyl]-amide===
-==Overview==
+<!--
-There remains a high unmet medical need for a safe oral therapy for thrombotic disorders. The serine protease factor Xa (fXa), with its central role in the coagulation cascade, is among the more promising targets for anticoagulant therapy and has been the subject of intensive drug discovery efforts. Investigation of a hit from high-throughput screening identified a series of thiophene-substituted anthranilamides as potent nonamidine fXa inhibitors. Lead optimization by incorporation of hydrophilic groups led to the discovery of compounds with picomolar inhibitory potency and micromolar in vitro anticoagulant activity. Based on their high potency, selectivity, oral pharmacokinetics, and efficacy in a rat venous stasis model of thrombosis, compounds ZK 814048 (10b), ZK 810388 (13a), and ZK 813039 (17m) were advanced into development.
+The line below this paragraph, {{ABSTRACT_PUBMED_17536795}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17536795 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17536795}}
 ==About this Structure==
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 [[Category: Protease]]
 [[Category: Protein inhibitor complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 12:17:22 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:56:46 2008''