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| {{STRUCTURE_2hnk| PDB=2hnk | SCENE= }} | | {{STRUCTURE_2hnk| PDB=2hnk | SCENE= }} |
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| '''Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans'''
| | ===Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans=== |
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| ==Overview==
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| The S-adenosylmethionine (SAM)-dependent O-methyltransferase from Leptospira interrogans (LiOMT) expressed by gene LA0415 belongs to the Methyltransf_3 family (Pfam PF01596). In this family all of the five bacterial homologues with known function are reported as SAM-dependent O-methylstransferases involved in antibiotic production. The crystal structure of LiOMT in complex with S-adenosylhomocysteine reported here is the first bacterial protein structure in this family. The LiOMT structure shows a conserved SAM-binding region and a probable metal-dependent catalytic site. The molecules of LiOMT generate homodimers by N-terminal swapping, which assists the pre-organization of the substrate-binding site. Based on the sequence and structural analysis, it is implied by the catalytic and substrate-binding site that the substrate of LiOMT is a phenolic derivative, which probably has a large ring-shaped moiety. | | The line below this paragraph, {{ABSTRACT_PUBMED_17561415}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17561415 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17561415}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Modified rossman fold]] | | [[Category: Modified rossman fold]] |
| [[Category: Transferase]] | | [[Category: Transferase]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:29:34 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:56:21 2008'' |