2adb: Difference between revisions

Revision as of 16:38, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2adb.png

Template:STRUCTURE 2adb

Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNASolution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA

Template:ABSTRACT PUBMED 16179478

About this StructureAbout this Structure

2ADB is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

ReferenceReference

Structure of PTB bound to RNA: specific binding and implications for splicing regulation., Oberstrass FC, Auweter SD, Erat M, Hargous Y, Henning A, Wenter P, Reymond L, Amir-Ahmady B, Pitsch S, Black DL, Allain FH, Science. 2005 Sep 23;309(5743):2054-7. PMID:16179478

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 {{STRUCTURE_2adb|  PDB=2adb  |  SCENE=  }}
-'''Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA'''
+===Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA===
-==Overview==
+<!--
-The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the solution structures of the four RNA binding domains (RBDs) of PTB, each bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel orientation of their bound RNAs. Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within the same RNA. This leads to structural models for how PTB functions as an alternative-splicing repressor.
+The line below this paragraph, {{ABSTRACT_PUBMED_16179478}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16179478 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16179478}}
 ==About this Structure==
-ADB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADB OCA].
+ADB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADB OCA].
 ==Reference==
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 [[Category: Rbd]]
 [[Category: Rrm]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:54:11 2008''
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