2k2o: Difference between revisions

Revision as of 16:34, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2k2o.png

Template:STRUCTURE 2k2o

Solution Structure of the inner DysF domain of human myoferlinSolution Structure of the inner DysF domain of human myoferlin

Template:ABSTRACT PUBMED 18495154

About this StructureAbout this Structure

2K2O is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

ReferenceReference

Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b., Patel P, Harris R, Geddes SM, Strehle EM, Watson JD, Bashir R, Bushby K, Driscoll PC, Keep NH, J Mol Biol. 2008 Jun 20;379(5):981-90. Epub 2008 Apr 26. PMID:18495154

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 {{STRUCTURE_2k2o|  PDB=2k2o  |  SCENE=  }}
-'''Solution Structure of the inner DysF domain of human myoferlin'''
+===Solution Structure of the inner DysF domain of human myoferlin===
-==Overview==
+<!--
-Mutations in the protein dysferlin, a member of the ferlin family, lead to limb girdle muscular dystrophy type 2B and Myoshi myopathy. The ferlins are large proteins characterised by multiple C2 domains and a single C-terminal membrane-spanning helix. However, there is sequence conservation in some of the ferlin family in regions outside the C2 domains. In one annotation of the domain structure of these proteins, an unusual internal duplication event has been noted where a putative domain is inserted in between the N- and C-terminal parts of a homologous domain. This domain is known as the DysF domain. Here, we present the solution structure of the inner DysF domain of the dysferlin paralogue myoferlin, which has a unique fold held together by stacking of arginine and tryptophans, mutations that lead to clinical disease in dysferlin.
+The line below this paragraph, {{ABSTRACT_PUBMED_18495154}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18495154 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18495154}}
 ==About this Structure==
-K2O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2O OCA].
+K2O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2O OCA].
 ==Reference==
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 [[Category: Polymorphism]]
 [[Category: Transmembrane]]
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