1zr5: Difference between revisions

Revision as of 16:30, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1zr5.png

Template:STRUCTURE 1zr5

Crystal structure of the macro-domain of human core histone variant macroH2A1.2Crystal structure of the macro-domain of human core histone variant macroH2A1.2

Template:ABSTRACT PUBMED 15965484

About this StructureAbout this Structure

1ZR5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Splicing regulates NAD metabolite binding to histone macroH2A., Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG, Nat Struct Mol Biol. 2005 Jul;12(7):624-5. Epub 2005 Jun 19. PMID:15965484

Page seeded by OCA on Mon Jul 28 16:30:04 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1zr5.gif|left|200px]]
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-'''Crystal structure of the macro-domain of human core histone variant macroH2A1.2'''
+===Crystal structure of the macro-domain of human core histone variant macroH2A1.2===
-==Overview==
+<!--
-Histone macroH2A is a hallmark of mammalian heterochromatin. Here we show that human macroH2A1.1 binds the SirT1-metabolite O-acetyl-ADP-ribose (OAADPR) through its macro domain. The 1.6-A crystal structure and mutants reveal how the metabolite is recognized. Mutually exclusive exon use in the gene H2AFY produces macroH2A1.2, whose tissue distribution differs. MacroH2A1.2 shows only subtle structural changes but cannot bind nucleotides. Alternative splicing may thus regulate the binding of nicotinamide adenine dinucleotide (NAD) metabolites to chromatin.
+The line below this paragraph, {{ABSTRACT_PUBMED_15965484}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15965484 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_15965484}}
 ==About this Structure==
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 [[Category: P-loop]]
 [[Category: Splicing]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:57:57 2008''
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