2acl: Difference between revisions

Revision as of 16:07, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2acl.png

Template:STRUCTURE 2acl

Liver X-Receptor alpha Ligand Binding Domain with SB313987Liver X-Receptor alpha Ligand Binding Domain with SB313987

Template:ABSTRACT PUBMED 16107141

About this StructureAbout this Structure

2ACL is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure., Jaye MC, Krawiec JA, Campobasso N, Smallwood A, Qiu C, Lu Q, Kerrigan JJ, De Los Frailes Alvaro M, Laffitte B, Liu WS, Marino JP Jr, Meyer CR, Nichols JA, Parks DJ, Perez P, Sarov-Blat L, Seepersaud SD, Steplewski KM, Thompson SK, Wang P, Watson MA, Webb CL, Haigh D, Caravella JA, Macphee CH, Willson TM, Collins JL, J Med Chem. 2005 Aug 25;48(17):5419-22. PMID:16107141

Page seeded by OCA on Mon Jul 28 16:07:01 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2acl.gif|left|200px]]
+{{Seed}}
+[[Image:2acl.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2acl|  PDB=2acl  |  SCENE=  }}
-'''Liver X-Receptor alpha Ligand Binding Domain with SB313987'''
+===Liver X-Receptor alpha Ligand Binding Domain with SB313987===
-==Overview==
+<!--
-Substituted 3-(phenylamino)-1H-pyrrole-2,5-diones were identified from a high throughput screen as inducers of human ATP binding cassette transporter A1 expression. Mechanism of action studies led to the identification of GSK3987 as an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC(50)s of 40 nM, profiles as an LXR agonist in functional assays, and activates LXR though a mechanism that is similar to first generation LXR agonists.
+The line below this paragraph, {{ABSTRACT_PUBMED_16107141}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16107141 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16107141}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Smallwood, A.]]
 [[Category: Nuclear hormone receptor ligand binding domain transcription factor three layered a-helix fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:52:53 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:07:01 2008''