1r09: Difference between revisions

Revision as of 14:52, 28 July 2008

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File:1r09.png

Template:STRUCTURE 1r09

HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837

Template:ABSTRACT PUBMED 1847215

About this StructureAbout this Structure

1R09 is a Protein complex structure of sequences from Human rhinovirus 14. Full crystallographic information is available from OCA.

ReferenceReference

Human rhinovirus 14 complexed with antiviral compound R 61837., Chapman MS, Minor I, Rossmann MG, Diana GD, Andries K, J Mol Biol. 1991 Feb 5;217(3):455-63. PMID:1847215

Page seeded by OCA on Mon Jul 28 14:52:46 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1r09.jpg|left|200px]]
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-'''HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837'''
+===HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837===
-==Overview==
+<!--
-The binding of the antirhinoviral agent R 61837 to human rhinovirus 14 has been examined by X-ray crystallographic methods. The compound R 61837 binds in the same pocket (underneath the canyon floor) as the "WIN" antirhinoviral agents. It does not penetrate as far into the pocket but causes similar conformational changes in the virus capsid. The movement of residues 1217 to 1221 of viral protein 1 (in the "FMDV loop") is more pronounced for R 61837 than for WIN compounds. Although both R 61837 and WIN antiviral agents partially fill the same hydrophobic pocket, atomic binding interactions differ, showing that considerable diversity in the nature of antiviral agents is possible.
+The line below this paragraph, {{ABSTRACT_PUBMED_1847215}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 1847215 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_1847215}}
 ==About this Structure==
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 [[Category: Icosahedral virus]]
 [[Category: Rhinovirus coat protein]]
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