2c0t: Difference between revisions

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[[Image:2c0t.gif|left|200px]]
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[[Image:2c0t.png|left|200px]]


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{{STRUCTURE_2c0t|  PDB=2c0t  |  SCENE=  }}  
{{STRUCTURE_2c0t|  PDB=2c0t  |  SCENE=  }}  


'''SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359'''
===SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359===




==Overview==
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We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.
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{{ABSTRACT_PUBMED_16216497}}


==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 21:04:23 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:53:41 2008''

Revision as of 13:53, 28 July 2008

File:2c0t.png

Template:STRUCTURE 2c0t

SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359

Template:ABSTRACT PUBMED 16216497

About this StructureAbout this Structure

2C0T is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection., Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF, Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10. PMID:16216497

Page seeded by OCA on Mon Jul 28 13:53:41 2008

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