1ypq: Difference between revisions

Revision as of 13:47, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1ypq.png

Template:STRUCTURE 1ypq

Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane ComplexHuman Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex

Template:ABSTRACT PUBMED 15695803

About this StructureAbout this Structure

1YPQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1., Park H, Adsit FG, Boyington JC, J Biol Chem. 2005 Apr 8;280(14):13593-9. Epub 2005 Feb 5. PMID:15695803

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OCA

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-'''Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex'''
+===Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex===
-==Overview==
+<!--
-The lectin-like oxidized low density lipoprotein receptor-1 (Lox-1) mediates the recognition and internalization of oxidatively modified low density lipoprotein by vascular endothelial cells. This interaction results in a number of pro-atherogenic cellular responses that probably play a significant role in the pathology of atherosclerosis. The 1.4 angstrom crystal structure of the extracellular C-type lectin-like domain of human Lox-1 reveals a heart-shaped homodimer with a ridge of six basic amino acids extending diagonally across the apolar top of Lox-1, a central hydrophobic tunnel that extends through the entire molecule, and an electrostatically neutral patch of 12 charged residues that resides next to the tunnel at each opening. Based on the arrangement of critical binding residues on the Lox-1 structure, we propose a binding mode for the recognition of modified low density lipoprotein and other Lox-1 ligands.
+The line below this paragraph, {{ABSTRACT_PUBMED_15695803}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_15695803}}
 ==About this Structure==
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 [[Category: Nk cell receptor]]
 [[Category: Oxidized low density lipoprotein receptor]]
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