1r2p: Difference between revisions

Revision as of 13:37, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1r2p.png

Template:STRUCTURE 1r2p

Solution structure of domain 5 from the ai5(gamma) group II intronSolution structure of domain 5 from the ai5(gamma) group II intron

Template:ABSTRACT PUBMED 14745440

About this StructureAbout this Structure

Full experimental information is available from OCA.

ReferenceReference

Solution structure of domain 5 of a group II intron ribozyme reveals a new RNA motif., Sigel RK, Sashital DG, Abramovitz DL, Palmer AG, Butcher SE, Pyle AM, Nat Struct Mol Biol. 2004 Feb;11(2):187-92. Epub 2004 Jan 25. PMID:14745440

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Solution structure of domain 5 from the ai5(gamma) group II intron'''
+===Solution structure of domain 5 from the ai5(gamma) group II intron===
-==Overview==
+<!--
-Domain 5 (D5) is the central core of group II intron ribozymes. Many base and backbone substituents of this highly conserved hairpin participate in catalysis and are crucial for binding to other intron domains. We report the solution structures of the 34-nucleotide D5 hairpin from the group II intron ai5 gamma in the absence and presence of divalent metal ions. The bulge region of D5 adopts a novel fold, where G26 adopts a syn conformation and flips down into the major groove of helix 1, close to the major groove face of the catalytic AGC triad. The backbone near G26 is kinked, exposing the base plane of the adjacent A-U pair to the solvent and causing bases of the bulge to stack intercalatively. Metal ion titrations reveal strong Mg(2+) binding to a minor groove shelf in the D5 bulge. Another distinct metal ion-binding site is observed along the minor groove side of the catalytic triad, in a manner consistent with metal ion binding in the ribozyme active site.
+The line below this paragraph, {{ABSTRACT_PUBMED_14745440}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14745440 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14745440}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2P OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2P OCA].
 ==Reference==
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 [[Category: Rna hairpin]]
 [[Category: Tetraloop]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:00:09 2008''
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